Exploration the Significance of a Novel Immune-Related Gene Signature in Prognosis and Immune Microenvironment of Breast Cancer

Exploration the Significance of a Novel Immune-Related Gene Signature in Prognosis and Immune Microenvironment of Breast Cancer

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This study was designed to identify an immune-related gene signature (IRGS) associated with breast cancer (BC) patient outcomes.Transcriptomic data from 1411 BC patients in the TCGA and GEO databases were used to identify differentially expressed vibrating table for chocolate immune-related genes (DEIGs) when comparing BC tumor and normal tissue samples.We were able to construct a 27-gene IRGS that was able to effectively separate BC patients into high- and low-risk groups that corresponded to significant differences in overall and recurrence-free survival (OS and RFS, respectively).Besides, the relevance of this signature to immune response and immune cell infiltration of BC tumors was evaluated.These high- and low-risk BC patients were found to exhibit significantly different immune responses and functional enrichment.

We also identified patients in the high-risk group exhibited significantly reduced immune cell infiltration of tumors relative to low-risk patients.Together, the results of this analysis offer a novel overview of the immune microenvironment within BC tumors and highlight key immunological genes iphone 14 price miami associated with patient survival outcomes.